Publications Archives | Dewpoint Therapeutics https://dewpointx.com/category/publications/ The Biomolecular Condensates Company Tue, 28 Jan 2025 21:31:48 +0000 en-US hourly 1 https://dewpointx.com/wp-content/uploads/2022/11/cropped-favicon-1-32x32.png Publications Archives | Dewpoint Therapeutics https://dewpointx.com/category/publications/ 32 32 High throughput platform for ALS drug discovery by using human iPSC-derived motor neurons https://dewpointx.com/high-throughput-platform-for-als-drug-discovery-by-using-human-ipsc-derived-motor-neurons/ Tue, 28 Jan 2025 21:30:19 +0000 https://dewpointx.com/?p=6633

Poster presented at the SLAS2025 International Conference > Download the PDF file

The post High throughput platform for ALS drug discovery by using human iPSC-derived motor neurons appeared first on Dewpoint Therapeutics.

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Poster presented at the SLAS2025 International Conference

> Download the PDF file

The post High throughput platform for ALS drug discovery by using human iPSC-derived motor neurons appeared first on Dewpoint Therapeutics.

]]> TDP-43 condensate modulation rescues TDP-43 loss of function in ALS patient-derived motor neurons and mouse models of TDP-43 proteinopathy https://dewpointx.com/tdp-43-condensate-modulation-rescues-tdp-43-loss-of-function-in-als-patient-derived-motor-neurons-and-mouse-models-of-tdp-43-proteinopathy-2/ Wed, 23 Oct 2024 12:00:00 +0000 https://dewpointx.com/?p=6427

Poster presented at the 2024 Annual NEALS Meeting > Download the PDF file

The post TDP-43 condensate modulation rescues TDP-43 loss of function in ALS patient-derived motor neurons and mouse models of TDP-43 proteinopathy appeared first on Dewpoint Therapeutics.

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Poster presented at the 2024 Annual NEALS Meeting

> Download the PDF file

The post TDP-43 condensate modulation rescues TDP-43 loss of function in ALS patient-derived motor neurons and mouse models of TDP-43 proteinopathy appeared first on Dewpoint Therapeutics.

]]> Introducing the Dewpoint-sponsored Nature Collection: “Liquid-liquid phase separation” https://dewpointx.com/introducing-the-dewpoint-sponsored-nature-collection-liquid-liquid-phase-separation/ Thu, 26 Sep 2024 15:35:01 +0000 https://dewpointx.com/?p=6389

We are proud to introduce the Dewpoint-sponsored Nature Collection titled “Liquid-liquid phase separation” – a compilation of prominent papers from […]

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We are proud to introduce the Dewpoint-sponsored Nature Collection titled “Liquid-liquid phase separation” – a compilation of prominent papers from the Nature Portfolio, independently selected by the editorial staff to showcase the latest developments in the field of biomolecular condensates science. 

https://www.nature.com/collections/iabcefgejd

The post Introducing the Dewpoint-sponsored Nature Collection: “Liquid-liquid phase separation” appeared first on Dewpoint Therapeutics.

]]> RNA and condensates: Disease implications and therapeutic opportunities https://dewpointx.com/rna-and-condensates-disease-implications-and-therapeutic-opportunities/ Fri, 20 Sep 2024 12:55:11 +0000 https://dewpointx.com/?p=6373

This article, authored by Tina Han, Bede Portz, Richard Young, Ann Boija, and Isaac Klein, was originally published in the […]

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This article, authored by Tina Han, Bede Portz, Richard Young, Ann Boija, and Isaac Klein, was originally published in the September 19, 2024 issue of Cell Chemical Biology.

Download the PDF file

The post RNA and condensates: Disease implications and therapeutic opportunities appeared first on Dewpoint Therapeutics.

]]> TDP-43 condensate modulation rescues TDP-43 loss of function in ALS patient-derived motor neurons and mouse models of TDP-43 proteinopathy https://dewpointx.com/tdp-43-condensate-modulation-rescues-tdp-43-loss-of-function-in-als-patient-derived-motor-neurons-and-mouse-models-of-tdp-43-proteinopathy/ Wed, 07 Aug 2024 13:58:05 +0000 https://dewpointx.com/?p=6284

Poster presented at the Gordon Research Conference – Neurobiology of Brain Disorders > Download the PDF file

The post TDP-43 condensate modulation rescues TDP-43 loss of function in ALS patient-derived motor neurons and mouse models of TDP-43 proteinopathy appeared first on Dewpoint Therapeutics.

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Poster presented at the Gordon Research Conference – Neurobiology of Brain Disorders

> Download the PDF file

The post TDP-43 condensate modulation rescues TDP-43 loss of function in ALS patient-derived motor neurons and mouse models of TDP-43 proteinopathy appeared first on Dewpoint Therapeutics.

]]> Leveraging the power of molecular communities https://dewpointx.com/leveraging-the-power-of-molecular-communities/ Thu, 25 Jul 2024 16:48:39 +0000 https://dewpointx.com/?p=6293

This article was originally published in the Drug Discovery World special eReport ‘Neuroscience: Advances in research and opportunities ahead’ and […]

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This article was originally published in the Drug Discovery World special eReport ‘Neuroscience: Advances in research and opportunities ahead’ and is reproduced here with permission.

> Download the PDF file (7 MB)

The post Leveraging the power of molecular communities appeared first on Dewpoint Therapeutics.

]]> Targeting colorectal cancer by sequestration of beta catenin in nuclear condensates https://dewpointx.com/targeting-colorectal-cancer-by-sequestration-of-beta-catenin-in-nuclear-condensates/ Thu, 27 Jun 2024 13:23:51 +0000 https://dewpointx.com/?p=6183

Poster presented at the ESMO Gastrointestinal Cancers Congress 2024 > Download the PDF file

The post Targeting colorectal cancer by sequestration of beta catenin in nuclear condensates appeared first on Dewpoint Therapeutics.

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Poster presented at the ESMO Gastrointestinal Cancers Congress 2024

> Download the PDF file

The post Targeting colorectal cancer by sequestration of beta catenin in nuclear condensates appeared first on Dewpoint Therapeutics.

]]> Development of a MeCP2 condensate-modifying small molecule for the treatment ​of Rett syndrome https://dewpointx.com/development-of-a-mecp2-condensate-modifying-small-molecule-for-the-treatment-of-rett-syndrome/ Tue, 18 Jun 2024 13:30:33 +0000 https://dewpointx.com/?p=6177

Poster presented at the 2024 International Rett Syndrome Foundation Scientific Meeting > Download the PDF file

The post Development of a MeCP2 condensate-modifying small molecule for the treatment ​of Rett syndrome appeared first on Dewpoint Therapeutics.

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Poster presented at the 2024 International Rett Syndrome Foundation Scientific Meeting

> Download the PDF file

The post Development of a MeCP2 condensate-modifying small molecule for the treatment ​of Rett syndrome appeared first on Dewpoint Therapeutics.

]]> Condensate modulator sequesters β-Catenin into depot condensates and demonstrates competitive anti-tumor activity in animal models of colorectal cancer https://dewpointx.com/condensate-modulator-sequesters-beta-catenin-into-depot-condensates-and-demonstrates-competitive-anti-tumor-activity-in-animal-models-of-colorectal-cancer/ Mon, 08 Apr 2024 20:29:14 +0000 https://dewpointx.com/?p=6012

Poster presented at the American Association for Cancer Research (AACR) Annual Meeting 2024 > Download the PDF file

The post Condensate modulator sequesters β-Catenin into depot condensates and demonstrates competitive anti-tumor activity in animal models of colorectal cancer appeared first on Dewpoint Therapeutics.

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Poster presented at the American Association for Cancer Research (AACR) Annual Meeting 2024

> Download the PDF file

The post Condensate modulator sequesters β-Catenin into depot condensates and demonstrates competitive anti-tumor activity in animal models of colorectal cancer appeared first on Dewpoint Therapeutics.

]]> The Power of High Content, High Throughput Screening in Condensate Based Drug Discovery https://dewpointx.com/the-power-of-high-content-high-throughput-screening-in-condensate-based-drug-discovery/ Mon, 05 Feb 2024 14:40:00 +0000 https://dewpointx.com/?p=5946

Poster presented at the Society for Laboratory Automation and Screening 2024 International Conference and Exhibition (SLAS2024) > Download the PDF […]

The post The Power of High Content, High Throughput Screening in Condensate Based Drug Discovery appeared first on Dewpoint Therapeutics.

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Poster presented at the Society for Laboratory Automation and Screening 2024 International Conference and Exhibition (SLAS2024)

> Download the PDF file

The post The Power of High Content, High Throughput Screening in Condensate Based Drug Discovery appeared first on Dewpoint Therapeutics.

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